DROSHA rs10719 T > C is associated with lymph node metastasis and clinical stage of gastric cancer patients

作者：Li, Jun; Liao, Yuqian^*; Liao, Yulu; Ruan, Shufang; Wan, Yiye; Peng, Lixiang

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(7): 7333-7339.

• DROSHA
• polymorphism
• gastric cancer
• prognosis

It has been proved that polymorphisms in DROSHA are related to the risk and outcomes of several cancers. In our study, 97 patients with stage I-III gastric cancer treated with radical gastrectomy and adjuvant chemotherapy of oxaliplatin and fluoropyrimidines were analyzed. MassARRAY MALDI-TOF system was used to determine the genotypes. The 2-year DFS rate was 60.8% and the 3-year OS rate was 73.8%. In dominant model, we found that rs10719 TC+CC genotype carriers were less likely to develop lymph node metastasis (P=0.031). Compared with TC+CC genotype carriers, more patients with TT genotype were in stage III (P=0.021). The 3-year OS was significantly different for patients with or without lymph node metastasis (89.3% vs 63.3%, P=0.013) and for patients with stage I-III disease (100.0%, 88.6% and 55.8%, P=0.015). After the multi-variants' cox regression analysis, lymph node status (P=0.014, RR: 9.556, 95% CI: 1.586-57.590) was found to be an independent prognostic factor for these patients. These results suggested that DROSHA rs10719 T > C may be associated with lymph node metastasis and clinical stage of gastric cancer in a Chinese population.

• 出版日期2017
• 单位江西省肿瘤医院