New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study

作者：Alkuraishy Hayder M; Al Gareeb Ali I

来源：Emergency Medicine International, 2015, 2015: 283021.

DOI：10.1155/2015/283021

<jats:p><jats:italic>Background</jats:italic>. Serum omentin-1 level was low in the most types of ischemic heart disease compared to normal subjects; it also dependently correlated with coronary heart disease; thus, omentin-1 is regarded as a novel biomarker in IHD.<jats:italic>Objective</jats:italic>. The aim of the present study was to establish the links between omentin-1 and acute myocardial infarction in metformin patients.<jats:italic>Subjects and Methods</jats:italic>. A cross-sectional study was performed on eighty-five patients with type II DM and acute MI. They are divided as follows: Group I, 62 patients with type II DM who received metformin prior to onset of acute MI; Group II, 23 patients with type II DM who did not receive metformin prior to onset of acute MI; and Group III, 30 normal healthy controls. Venous blood was drawn from each participant for determination of lipid profile, plasma omentin-1, cardiac troponin-I (cTn-I) and other routine tests.<jats:italic>Results</jats:italic>. Patients that presented with acute MI that received metformin show a significant difference in all biochemical parameters (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn fontstyle="italic">0.001</mml:mn></mml:math>); metformin increases serum omentin-1 level and decreases serum cardiac troponin-I level compared with control subjects and nonmetformin treated patients.<jats:italic>Conclusion</jats:italic>. Metformin pharmacotherapy increases omentin-1 serum levels and may be regarded as a potential agent in the prevention of the occurrences of acute MI in diabetic patients.</jats:p>

• 出版日期2015