Detection of Lactate With a Hadamard Slice Selected, Selective Multiple Quantum Coherence, Chemical Shift Imaging Sequence (HDMD-SelMQC-CSI) on a Clinical MRI Scanner: Application to Tumors and Muscle Ischemia

作者：Mellon Eric A^*; Lee Seung Cheol; Pickup Stephen; Kim Sungheon; Goldstein Steven C; Floyd Thomas F; Poptani Harish; Delikatny E James; Reddy Ravinder; Glickson Jerry D

来源：Magnetic Resonance in Medicine, 2009, 62(6): 1404-1413.

DOI：10.1002/mrm.22141

• lactate imaging
• Hadamard encoding
• non-Hodgkin's lymphoma
• blood flow occlusion
• magnetic resonance spectroscopy

Lactate is an important metabolite in normal and malignant tissues detectable by NMR spectroscopy; however, it has been difficult to clinically detect the lactate methyl resonance because it is obscured by lipid resonances. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate resonances. We implemented a three-dimensional selective homonuclear multiple quantum coherence transfer version with Hadamard slice selection and two-dimensional phase encoding (Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging) on a conventional clinical MR scanner. Hadamard slice selection is explained and demonstrated in vivo. This is followed by 1-cm(3) resolution lactate imaging with detection to 5-mM concentration in 20 min on a 3-T clinical scanner. An analysis of QSel gradient duration and amplitude effects on lactate and lipid signal is presented. To demonstrate clinical feasibility, a 5-min lactate scan of a patient with a non-Hodgkin's lymphoma in the superficial thigh is reported. The elevated lactate signal coincides with the T(2)-weighted image of this tumor. As a test of selective homonuclear multiple quantum coherence transfer sensitivity, a thigh tourniquet was applied to a normal volunteer and an increase in lactate was detected immediately after tourniquet flow constriction. In conclusion, the Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging sequence is demonstrated on a phantom and in two lipid-rich, clinically relevant, in vivo conditions. Magn Reson Med 62:1404-1413, 2009.

• 出版日期2009-12