N staging of lung cancer patients with PET/MRI using a three-segment model attenuation correction algorithm: Initial experience

作者：Kohan A A^*; Kolthammer J A; Vercher Conejero J L; Rubbert C; Partovi S; Jones R; Herrmann K A; Faulhaber P

来源：European Radiology, 2013, 23(11): 3161-3169.

DOI：10.1007/s00330-013-2914-y

• PET/MRI
• Lung cancer
• N staging
• PET/CT
• F18-FDG

Evaluate the performance of PET/MRI at tissue interfaces with different attenuation values for detecting lymph node (LN) metastases and for accurately measuring maximum standardised uptake values (SUVmax) in lung cancer patients. %26lt;br%26gt;Eleven patients underwent PET/CT and PET/MRI for staging, restaging or follow-up of suspected or known lung cancer. Four experienced readers determined the N stage of the patients for each imaging method in a randomised blinded way. Concerning metastases, SUVmax of FDG-avid LNs were measured in PET/CT and PET/MRI in all patients. A standard of reference was created with a fifth experienced independent reader in combination with a chart review. Results were analysed to determine interobserver agreement, SUVmax correlation between CT and MRI (three-segment model) attenuation correction and diagnostic performance of the two techniques. %26lt;br%26gt;Overall interobserver agreement was high (kappa = 0.86) for PET/CT and substantial (kappa = 0.70) for PET/MRI. SUVmax showed strong positive correlation (Spearman%26apos;s correlation coefficient = 0.93, P %26lt; 0.001) between the two techniques. Diagnostic performance of PET/MRI was slightly inferior to that of PET/CT, without statistical significance (P %26gt; 0.05). %26lt;br%26gt;PET/MRI using three-segment model attenuation correction for LN staging in lung cancer shows a strong parallel to PET/CT in terms of SUVmax, interobserver agreement and diagnostic performance. %26lt;br%26gt;aEuro cent F18-FDG PET/MRI shows similar performance to F18-FDG PET/CT in lung cancer N staging. %26lt;br%26gt;aEuro cent PET/MRI has substantial interobserver agreement in N staging. %26lt;br%26gt;aEuro cent A three-segment model attenuation correction is reliable for assessing the mediastinum.

• 出版日期2013-11