An Asymmetric, Catalytic (4+3) Cycloaddition Reaction of Cyclopentenyl Oxyallylic Cations

作者:Topinka Michael; Zawatzky Kerstin; Barnes Charles L; Welch Christopher J; Harmata Michael*
来源:Organic Letters, 2017, 19(15): 4106-4109.
DOI:10.1021/acs.orglett.7b01868

摘要

Treatment of 2-tosyloxycyclopentanone with substituted furans in the presence of a chiral amino alcohol catalyst and K2HPO4 results in the formation of (4 + 3) cycloaddition products with enantioselectivities that exceed 90% in certain cases.

  • 出版日期2017-8-4