Asymmetric metal free beta-boration of alpha,beta-unsaturated imines assisted by (S)-MeBoPhoz

作者：La Cascia Enrico; Sanz Xavier; Bo Carles; Whiting Andrew^*; Fernandez Elena

来源：Organic and Biomolecular Chemistry, 2015, 13(5): 1328-1332.

DOI：10.1039/c4ob02478h

The adduct [MeO -> Bpin-Bpin](-) efficiently mediates the beta-boration of alpha,beta-unsaturated imines formed in situ. The use of chiral phosphines as additives, and in particular the chiral phosphine (S)-MeBoPhoz, enables the catalytic asymmetric reaction to proceed with higher enantioselectivity than the analogue copper(I) mediated reaction.

• 出版日期2015