科研之友
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摘要
Applanatumols A (1) and B [(+/-)-2], two unique meroterpenoids with a novel spiro[ benzofuran-2,2'-bicyclo [3.2.2]nonane] ring system and a naturally unusual dioxacyclopenta[cd]inden motif, respectively, were isolated from Ganoderma applanatum. Their structures were determined using spectroscopic data. In particular, the absolute configurations of 1 and 2 were assigned by X-ray diffraction analysis using the Flack parameter and ECD calculations, respectively. A plausible biosynthetic pathway for 1 and 2 is proposed. The biological activities of 1 and 2 against renal fibrosis were accessed in rat proximal tubular epithelial cells.
- 出版日期2016
- 单位广东药科大学; 植物化学与西部植物资源持续利用国家重点实验室; 中国科学院大学; 中国科学院昆明植物研究所
