科研之友
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摘要
A simple, green and highly efficient approach for the one-pot three-component synthesis of beta-phosphonomalonates has been developed. In the presence of the quaternary ammonium salt catalysts, the beta-phosphonomalonates were obtained in excellent yields within short times via tandem Knoevenagel-phospha-Michael reaction. The reaction of aldehydes/ketones, active methylene compounds, and diethyl phosphite performed at room temperature under solvent-free conditions. No column purification is required and the products can be purified by simple crystallization. The catalysts can be easily recovered and reused several times without significant activity loss.
