Actin related protein 3 (ARP3) promotes apoptosis of intestinal epithelial cells in ulcerative colitis

作者：Zhang, Shi-Qing; Ni, Wen-Kai; Xiao, Ming-Bing; Jiang, Feng; Lu, Cui-hua; Wang, Rui-Hua^*; Ni, Run-Zhou^*

来源：Pathology Research and Practice, 2019, 215(2): 235-242.

DOI：10.1016/j.prp.2018.10.011

• IBD
• Apoptosis
• ARP3

Apoptosis in intestinal epithelial cells (IECs) promotes the development of ulcerative colitis (UC), a type of inflammatory bowel disease (IBD). Efficient clearance of apoptotic cells is essential for tissue homeostasis in metazoans. Actin related protein 3 (ARP3) promotes endothelial dysfunction. The expression and function of ARP3 in UC remains unclear. In this study, the expression of apoptotic markers as p53, Bax, Cleaved-Caspease9 and Cleaved-Caspease3 were proved to be increased in the intestinal epithelial cells (IECs) of UC patients and in a mouse disuccinimidyl suberate(DSS)-induced colitis model; meanwhile, ARP3 expression was elevated. ARP3 expression levels and the severity of symptoms in patients with UC were positively correlated. By knocking down ARP3 in a TNF-alpha-treated NCM-460 cell colitis model, the apoptotic markers described above were all decreased. In conclusion, our data indicates that ARP3 might promote the apoptosis of IECs in UC, revealing a potential molecular target for treating UC.

• 出版日期2019-2
• 单位南通大学; 南方医科大学