An Efficient Synthesis of Hydantoins via Sustainable Integration of Coupled Domino Processes

作者：Gao, Meng; Yang, Yan; Wu, Yan-Dong; Deng, Cong; Shu, Wen-Ming; Zhang, Dong-Xue; Cao, Li-Ping; She, Neng-Fang; Wu, An-Xin^*

来源：Organic Letters, 2010, 12(18): 4026-4029.

DOI：10.1021/ol1015948

• MICROWAVE-ASSISTED SYNTHESIS
• CONJUGATED SCHIFF-BASES
• BETA-AMINO ESTERS
• TANDEM CATALYSIS
• MULTICOMPONENT REACTIONS
• ORGANIC-SYNTHESIS
• STRATEGY
• KETONES
• THIOHYDANTOINS
• CONSTRUCTION

A highly efficient synthesis of hydantoins has been developed from simple and commercially available 1,3-dicarbonyl compounds, ureas, and methyl ketones or terminal aryl alkenes. This protocol involves a sustainable integration of two coupled domino processes: iodine-promoted synthesis of unsymmetrical 1,4-enediones (domino I) and the sequential transformation into hydantoins (domino II).

• 出版日期2010-9-17
• 单位华中师范大学