Determination of beta-ODAP by various methods with special emphasis on biosensors: A mini-review

作者：Pundir C S^*; Batra Bhawna

来源：Process Biochemistry, 2015, 50(12): 2078-2087.

DOI：10.1016/j.procbio.2015.09.021

• Beta-ODAP
• Neurolathyrism
• Lathyrus
• Biosensors
• Nanoparticles

beta-N-oxalyl-L,alpha,beta-diaminopropionic acid (beta-ODAP), a neurotoxin is found in the seeds of grass pea (Lathyrus sativus). The excessive consumption of beta-ODAP by humans in several parts of Asia and Africa is known to cause neurolathyrism, an upper motor neuron degenerative disease, characterized by a spastic paraplegia. This review summarizes the principles, merits, demerits and various methods for determination of beta-ODAP, with special emphasis on beta-ODAP biosensors. The performance of beta-ODAP sensors could be improved by tailoring the properties of the interface with nanoparticles through engineering morphology, particle size, effective surface area, functionality, adsorption capability and electron-transfer properties.

• 出版日期2015-12