Microfluidics analysis of nanoparticle mixing in a microchannel system

作者：Li Jie; Kleinstreuer Clement^*

来源：Microfluidics and Nanofluidics, 2009, 6(5): 661-668.

DOI：10.1007/s10404-008-0341-1

• Microfluidics
• Nanofluid
• Micro-mixer
• Heat and mass transfer
• Nanodrug delivery

The microfluidics of controlled nanodrug delivery to living cells in a representative, partially heated microchannel was analyzed, using a validated computer model. The objective was to achieve uniform nanoparticle exit concentrations at a minimum microchannel length with the aid of simple static mixers, e.g., a multi-baffle-slit or perforated injection micro-mixer. A variable wall heat flux, which influences the local nanofluid properties and carrier-fluid velocities, was added to ensure that mixture delivery to the living cells occurred at the required (body) temperature of 37A degrees C. The results show that both the baffle-slit micro-mixer and the perforated injection micro-mixer aid in decreasing the microchannel length while achieving uniform nanoparticle exit concentrations. The injection micro-mixer not only decreases best the system's dimension, but also reduces the system power requirement. The baffle-slit micro-mixer also decreases the microchannel length; however, it may add to the power requirement. The imposed wall heat flux aids in enhanced nanoparticle and base-fluid mixing as well.

• 出版日期2009-5