Autoantibodies other than Anti-desmogleins in Pemphigus Vulgaris Patients

作者：Saleh Marwah Adly^*; Salem Hedayat; El Azizy Hoda

来源：Indian Journal of Dermatology, 2017, 62(1): 47-51.

DOI：10.4103/0019-5154.198032

• Anti-mitochondrial antibodies
• antinuclear antibodies
• antinuclear cytoplasmic antibodies
• anti-parietal antibodies
• anti-smooth muscle antibodies
• autoantibodies
• autoimmune bullous diseases
• pemphigus vulgaris

Background: Pemphigus vulgaris (PV) is an immunoglobulin G-mediated autoimmune bullous skin disease. Nonorgan-specific antibodies were detected in Tunisian and Brazilian pemphigus patients with different prevalence. Materials and Methods: Fifty PV patients and fifty controls were screened for antinuclear antibodies (ANAs), anti-smooth muscle antibodies (ASMAs), anti-parietal antibodies (APAs), anti-mitochondrial antibodies, and Anti-nuclear cytoplasmic antibodies (ANCA) by indirect immunofluorescence. Results: Thirty-nine patients were female and 11 were male. Fifteen patients did not receive treatment before while 35 patients were on systemic steroid treatment +/- azathioprine. Twenty (40%) of the PV patients and 1 (2%) control had positive ANA. ANA was significantly higher in PV patients than controls, P < 0.0001. ASMAs were detected in 20 (40%) PV patients and none of the controls. ASMA was significantly higher in PV patients than controls, P < 0.0001. No significant difference was detected between treated and untreated regarding ANA, P -0.11. However, there was a significant difference between treated and untreated regarding ASMA, P -0.03. Six patients (12%) and none of the controls had positive APA. There was a significant difference between the patients and the controls in APA. P -0.027. Conclusion: Egyptian PV patients showed more prevalent ANA, ASMA, and APA than normal controls. Follow-up of those patients is essential to detect the early development of concomitant autoimmune disease. Environmental factors might account for the variability of the nonorgan-specific antibodies among different populations.

• 出版日期2017-2