Apoptosis pathways and oncolytic adenoviral vectors: promising targets and tools to overcome therapy resistance of malignant melanoma

作者：Eberle Juergen^*; Fecker Lothar F; Hossini Amir M; Kurbanov Bahtier M; Fechner Henry

来源：Experimental Dermatology, 2008, 17(1): 1-11.

DOI：10.1111/j.1600-0625.2007.00655.x

• apoptosis
• Bcl-2 proteins
• death ligands
• melanoma
• oncolytic adenoviral vectors

In the last decades melanoma incidence has been increasing worldwide, while mortality remained on a high level. Until now, there is no suitable therapy for metastasized melanoma, which could lead to a significant increase in overall survival. Apoptosis deficiency is supposed to be a critical factor for therapy resistance, and previous work has characterized the basic mechanisms of apoptosis regulation in melanoma. Genes and strategies suitable for efficient induction of apoptosis in melanoma cells were identified, which are based on proapoptotic Bcl-2 proteins (Bcl-x(S), Bcl-x(AK), Bik/Nbk and Bax) as well as on tumor necrosis factor (TNF)-related death ligands (CD95L/Fas ligand and TNF-related apoptosis-inducing ligand, TRAIL). Proapoptotic genes may be employed in improved gene therapeutic strategies, based on conditional oncolytic adenoviral vectors.

• 出版日期2008-1