An Aza-Prins Cyclization Approach to Functionalized Indolizidines from 2-Allylpyrrolidines

作者：Liu Xiaoxi; McCormack Michael P; Waters Stephen P^*

来源：Organic Letters, 2012, 14(21): 5574-5577.

DOI：10.1021/ol302693u

The stereoselective synthesis of a diverse set of functionalized indolizidine systems has been accomplished through the aza-Prins cyclization of 2-allylpyrrolidines. The condensation of aldehydes onto 2-allylpyrrolidines yields iminium ions that undergo highly diastereoselective aza-Prins cyclization, producing up to two stereogenic centers and two new rings in one step.

• 出版日期2012-11-2