Multi-residual analysis of 16 beta-agonists in pig liver, kidney and muscle by ultra performance liquid chromatography tandem mass spectrometry

作者：Shao Bing^*; Jia Xiaofei; Zhang Jing; Meng Juan; Wu Yongning; Duan Hejun; Tu Xiaoming

来源：Food Chemistry, 2009, 114(3): 1115-1121.

DOI：10.1016/j.foodchem.2008.10.063

• beta-Agonists
• UPLC-ESI-MS/MS
• Solid phase extraction

A delicate method was developed for simultaneous analysis of 16 illegal residual beta-agonists in pork tissues including liver, kidney and meat. The samples were subjected to enzymatic hydrolysis, extracted with perchloric acid. and then dual Oasis HLB and MCX solid phase extraction (SPE) cartridges were used for cleanup. The analytes were quantified by ultra performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry (UPLC-ESI-MS/MS) operating in positive multiple-reaction mode (MRM). Matrix-fortified calibration curves were performed to compensate for the matrix effect and loss in sample preparation. CC alpha and CC beta of the analytes upon the method ranged from 0.02 to 0.79 mu g/kg and from 0.04 to 1.62 mu g/kg. respectively.

• 出版日期2009-6-1
• 单位中国疾病预防控制中心; 首都医科大学