A training program for primary care physicians improves the effectiveness of ultrasound surveillance of hepatocellular carcinoma

作者：Del Poggio Paolo; Olmi Stefano; Ciccarese Francesca; Mazzoleni Marzio; Jazzetti Michele; Jamoletti Carlo; Mattiello Mario; del Poggio Anna; Portugali Vanessa; Stroffolini Tommaso

来源：European Journal of Gastroenterology and Hepatology, 2015, 27(9): 1103-1108.

DOI：10.1097/MEG.0000000000000404

• cirrhosis
• hepatocellular carcinoma
• primary healthcare
• ultrasound surveillance

Background and aimsCirrhosis is the main risk factor of hepatocellular carcinoma (HCC), but only a minority of cirrhotic patients are referred to the hepatologist by primary care physicians (PCP) and receive regular ultrasound surveillance. The aim of this study was to determine whether a training program targeted to PCP could enhance the effectiveness of surveillance in a real-life setting.Patients and methodsA total of 120 PCP in an Italian area with a high incidence of HCC were trained to identify cirrhotic patients, to refer them to the Hepatology Centers of the area, and to start regular ultrasound surveillance. Clinical characteristics, outcome of treatments, and survival of 190 consecutive HCC patients in the same centers after training were compared with 244 HCC referred from the same area before training, and to 232 HCC referred by untrained PCP from other areas.ResultsTrained PCP referred significantly more HCC patients detected under surveillance and at an early stage (Barcelona Clinic Liver Cancer-A), suitable for radical treatments. In the intervention area, the 3 and 5-year survival of HCC patients increased after training from 35 to 48% and from 20 to 40%, respectively (P<0.05). In contrast, survival was unchanged in the other areas. At multivariate analysis, independent predictors adversely affecting survival were Child-Pugh B-C, -fetoprotein more than 10ng/dl, nonviral etiology, intermediate/advanced Barcelona Clinic Liver Cancer stage, and referral by an untrained PCP.ConclusionSpecific training of PCP aimed at the identification and referral of cirrhotic patients efficiently improves HCC survival.

• 出版日期2015-9