Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage

作者：Liu Chaodong^*; Wang Xian Zhong; Sun Xin Bo

来源：Early Human Development, 2013, 89(2): 95-100.

DOI：10.1016/j.earlhumdev.2012.08.003

• Sperm
• Recurrent miscarriage
• Regulatory T cell
• Human study
• Pregnancy

Background and aims: The prevalence of recurrent miscarriage (RM) is about 1-3% of women; the pathogenesis of RM is not fully understood yet. This study aims to assess the sperm antigen specific regulatory T cells (Treg) in women with RM.
Methods: A group of women with RM was recruited into this study. The sperm antigen was extracted from the semen samples of each woman's husband. The sperm antigen specific T cell response was assessed by flow cytometry.
Results: Low frequency of sperm specific Tregs and high frequency of T helper (Th)1 cells were detected in RM women as compared with women without RM. The sperm specific Tregs in RM women expressed less Ubc13. Knockdown of Ubc13 from Tregs converted the Tregs to effector T cells.
Conclusions: Immune deregulation may play an important role in RM.

• 出版日期2013-2
• 单位重庆医科大学