Molecular Evolution of Respiratory Syncytial Virus Fusion Gene, Canada, 2006-2010

作者：Papenburg Jesse; Carbonneau Julie; Hamelin Marie Eve; Isabel Sandra; Bouhy Xavier; Ohoumanne Najwa; Dery Pierre; Paes Bosco A; Corbeil Jacques; Bergeron Michel G; De Serres Gaston; Boivin Guy^*

来源：Emerging Infectious Diseases, 2012, 18(1): 120-124.

DOI：10.3201/eid1801.110515

To assess molecular evolution of the respiratory syncytial virus (RSV) fusion gene, we analyzed RSV-positive specimens from 123 children in Canada who did or did not receive RSV immunoprophylaxis (palivizumab) during 2006-2010. Resistance-conferring mutations within the palivizumab binding site occurred in 8.7% of palivizumab recipients and none of the nonrecipients.

• 出版日期2012-1