Association of bone-derived biomarkers with vascular calcification in chronic hemodialysis patients

作者：Lee Yueh Ting; Ng Hwee Yeong; Chiu Terry Ting Yu; Li Lung Chih; Pei Sung Nan; Kuo Wei Hung; Lee Chien Te

来源：Clinica Chimica Acta, 2016, 452: 38-43.

DOI：10.1016/j.cca.2015.10.031

• Vascular calcification
• DKK-1
• Sclerostin
• FGF23
• Hemodialysis

Background: Abdominal aortic calcification (AAC) is commonly observed in chronic dialysis patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AAC and analyze the relationship between bone-derived biomarkers and AAC.
Methods: We enrolled 227 stable hemodialysis patients. Vascular calcifications were assessed using lateral lumbar radiography of the abdominal aorta. Demographic data were collected and serum levels of biochemical and bone-derived biomarkers, including sclerostin, Dickkopf-1 (DKR-1), and fibroblast growth factor 23 (FGF23), were measured.
Results: One hundred sixty-one patients (71.0%) had MC. Patients with MC score 13 were older, with higher body mass index (BMI), serum calcium, calcium phosphate product, high-sensitivity C-reactive protein (hsCRP), and FGF23 levels. Sclerostin and DKK-1 levels were inversely associated with AAC severity, and FGF23 was directly related to vascular calcification. Hypertension, vascular disease, hsCRP, FGF23, and sclerostin were independent AAC determinants.
Conclusions: Chronic hemodialysis patients have a high prevalence of vascular calcifications. Levels of circulating sclerostin, DKK-1, and FGF23 were related to AAC severity. Sclerostin and FGF23 were independently associated with MC.

• 出版日期2016-1-15
• 单位长春大学