APOE epsilon 4 Is Associated With Exacerbation of Cognitive Decline in Patients With Multiple Sclerosis

作者：Shi Jiong^*; Tu Jiang Long; Gale Shawn D; Baxter Leslie; Vollmer Timothy L; Campagnolo Denise I; Tyry Tuula M; Zhuang Yi; Kuniyoshi Sandra M

来源：Cognitive and Behavioral Neurology, 2011, 24(3): 128-133.

DOI：10.1097/WNN.0b013e31823380b5

• multiple sclerosis
• cognition
• apolipoprotein E
• neuroimmunology

Background: In previous studies we and others have demonstrated an association with apolipoprotein (APOE) epsilon 4 genotype and the presence of cognitive deficits in multiple sclerosis (MS). In this follow-up study, we have assessed whether APOE epsilon 4 status exacerbates progression of cognitive deficits in MS.
Methods: A total of 197 patients with MS were assessed for APOE genotype, and baseline cognitive performance was measured using a standardized battery of tests. One hundred seventy patients (86.3%) were clinically followed up for 1 year and were assessed for progression of cognitive deficits.
Results: The APOE epsilon 4 allele was present in 24.7% of patients. During 1-year follow-up, significant progression of cognitive deficits was found in APOE epsilon 4 carriers (P = 0.001) after logistic regression analysis controlling for sex, ethnicity, age, education, disease duration, severity, and subtype.
Conclusions: APOE epsilon 4 carriers with MS have worsening progression of cognitive deficits than noncarriers. APOE epsilon 4 carrier status predicts cognitive decline in verbal learning and memory.

• 出版日期2011-9