Association between serum uric acid, metabolic syndrome and microalbuminuria in previously untreated essential hypertensive patients

作者：Rodilla Enrique; Perez Lahiguera Francisco; Costa Jose A; Gonzalez Carmen; Miralles Amparo; Moral Desamparados; Maria Pascual Jose

来源：Medicina Clinica, 2009, 132(1): 1-6.

DOI：10.1016/j.medcli.2008.07.008

• Microalbuminuria
• Metabolic syndrome
• Hyperuricemia

Background and objective: The aim of the study was to assess the association of serum uric acid levels with microalbuminuria -urinary albumin excretion (UAE)>= 30 mg/24 h-.
Patients and method: Cross-sectional study in 429 (220 women) hypertensive, non diabetic, never treated patients (mean age: 47 years) with glomerular filtration rate 60 ml/min/1.73 m(2).
Results: The prevalence of microalbuminuria was 20.5%; 18% had hyperuricemia and 47% fulfilled the criteria for metabolic syndrome (MS). Baseline UAE correlated in the unvaried analysis to diastolic blood pressure, waist circumference, high-density lipoprotein cholesterol and uric acid. In multiple linear regression models, only MS (beta = 0.113; p = 0.03), and serum uric acid values (beta = 0.04; p = 0.05) were independently associated with logUAE, after adjustment for age and sex. Hyperuricemia (serum uric acid level >= 7.0 mg/dl for men and : >= 6.5 mg/dl for women; odds ratio = 2.18: 95% confidence interval, 1.21-3.92; p = 0.010), and MS (odds ratio = 2.16; 95% confidence interval, 1.32-3.53: p = 0.002) were independently associated with a higher risk of microalbuminuria in multiple logistic regression analyses. The prevalence of microalbuminuria was 45.8% in patients with coexistent MS and hyperuricemia, as compared to 13.6% in hypertensive patients without it (p<0.001). In patients with concomitant MS and hyperuricemia the probability of being microalbuminuric was 3.7 times higher than in patients without those factors.
Conclusion: Serum uric acid level is associated with microalbuminuria. Coexistence of MS and hyperuricemia in hypertensive patients increases almost 4 times the odds of being microalbuminuric.

• 出版日期2009-1-17