A resource for cell line authentication, annotation and quality control

作者:Yu Mamie; Selvaraj Suresh K; Liang Chu May M Y; Aghajani Sahar; Busse Matthew; Yuan Jean; Lee Genee; Peale Franklin; Klijn Christiaan; Bourgon Richard; Kaminker Joshua S; Neve Richard M*
来源:Nature, 2015, 520(7547): 307-+.
DOI:10.1038/nature14397

摘要

Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will enable our community to eradicate the use of misidentified lines and generate credible cell-based data.

  • 出版日期2015-4-16