Distributional characteristics of vesicular monoamine transporter 2 in human embryonic brain and their correlation with Parkinson's disease

作者：Tian Xiangyang; Sun Zhujuan; Ding Xinsheng; Min Min; Sun Xingzhen^*

来源：African Journal of Pharmacy and Pharmacology, 2012, 6(34): 2531-2535.

DOI：10.5897/AJPP12.461

• Parkinson's disease
• vesicular monoamine transporter 2 (VMAT(2))
• immunohistochemistry
• tyrosine hydroxylase
• human fetus

The aim of this study was to observe the distributional characteristics of vesicular monoamine transporter 2 (VMAT(2)), in human embryonic brain tissues and explore the relationship of these characteristics with Parkinson's disease (PD). The distribution of VMAT(2) and tyrosine hydroxylase (TH) in substantia nigra pars compacta (SNC), ventral tegmental area (VTA) and locus coeruleus (LC) of human embryonic brains of different gestational ages was observed using immunohistochemistry and western blot analysis. VMAT2 expression in SNC was significantly lower than that in VTA and LC (P < 0.05). VMAT(2) expression in SNC is lower than that in VTA and LC. The weakened protective function of VMAT(2) may be an important cause for the selective loss of dopaminergic neurons in SNC caused by PD.

• 出版日期2012-9
• 单位南京医科大学