科研之友
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摘要
A novel strategy was developed for a rapid access to the naturally occurring racemic neoclausenamide and its analogs, which featured a highly erythro-selective vinylogous Mukaiyama type reaction (dr=12:1) and a highly diastereoselective tandem conjugate addition-Davis oxidation of N-Boc-pyrrol-2(5H)-one 5 (dr=10:1). Remarkably, the skeleton of neoclausenamide, namely 8a, an analog of neoclausenamide, was built in just two steps with all the four stereogenic centers (relative stereochemistry) established correctly and in excellent diastereoselectivities.
- 出版日期2012-9
- 单位厦门大学
