dnaX36 Mutator of Escherichia coli: Effects of the tau Subunit of the DNA Polymerase III Holoenzyme on Chromosomal DNA Replication Fidelity

作者:Gawel Damian; Jonczyk Piotr; Fijalkowska Iwona J; Schaaper Roel M*
来源:Journal of Bacteriology, 2011, 193(1): 296-300.
DOI:10.1128/JB.01191-10

摘要

The Escherichia coli dnaX36 mutant displays a mutator effect, reflecting a fidelity function of the dnaX-encoded tau subunit of the DNA polymerase III (Pol III) holoenzyme. We have shown that this fidelity i) applies to both leading- and lagging-strand synthesis, (ii) is independent of Pol IV, and (iii) is limited by Pol II.

  • 出版日期2011-1