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摘要
Functionalized 3-bromocoumarins 2 have been prepared by a simple one-pot bromination/Wittig/cyclization tandem process from methyl (triphenylphosphoranylidene) acetate, N-bromosuccinimide and a series of 2-hydroxybenzaldehydes. Owing to the commercial availability of salicylaldehyde derivatives, this approach offers such a diverse range of compounds that it. fulfills the recent demand for the generation of large combinatorial chemical libraries based on the coumarin scaffold.
- 出版日期2010-2
