SODB reduced obesity markers in hamsters Beneficial effects in hepatic and adipose tissue by modulating oxidative status

作者：Carillon Julie; Lacan Dominique; Rouanet Jean Max^*

来源：Agro Food Industry Hi-Tech, 2014, 25(4): 14-17.

• adipose tissue
• antioxidant defences
• insulin sensitivity
• liver
• melon superoxide dismutase
• metabolic syndrome

Obesity-related metabolic syndrome is often associated with an increased oxidative stress and a decrease of insulin sensitivity, inducing several modifications, particularly in adipose tissue. However, dietary antioxidants could prevent oxidative stress and insulin-induced damage. In this context, we evaluated the effects of a 1-month curative supplementation with SODB, a melon SOD, on the liver and adipose tissue of obese hamsters. SODB reduced body weight and obesity markers. These beneficial effects could be due to the increased expression of tissular antioxidant defense proteins. These findings suggest that SODB could exert its antioxidant properties by inducing the endogenous antioxidant defense. The mechanisms underlying this induction need to be further investigated.

• 出版日期2014-8