A novel and effective delivery method for polyglycolic acid sheets to post-endoscopic submucosal dissection ulcers

作者：Takao Toshitatsu^*; Takegawa Yoshitaka; Ono Hiroyuki; Takao Madoka; Oka Shiro; Shinya Noriko; Kutsumi Hiromu; Azuma Takeshi

来源：Endoscopy, 2017, 49(4): 359-364.

DOI：10.1055/s-0042-120997

Background and aims Shielding methods for post-endoscopic submucosal dissection (ESD) ulcers have delivery-related problems. We developed an enveloped device for this purpose and evaluated its usefulness.
Materials and methods Polyglycolic acid (PGA) sheets were delivered to six 3.0-cm ulcers in two resected porcine stomachs and six 5.0-cm ulcers in another three stomachs. In the regular method group, small PGA sheets were delivered via forceps. In the novel method group, a large PGA sheet was delivered via the new device. The methods were compared in terms of time, and macroscopic and histological findings of the ulcer floor.
Results The median time required to cover a 3.0-cm ulcer was 0.39 min/cm(2) in the novel method group and 1.03 min/cm(2) in the regular method group (P = 0.03), and to cover a 5.0-cm ulcer was 0.38 min/cm(2) and 0.85 min/cm(2), respectively (P = 0.03). In the novel method group, the PGA sheets were in close contact, fully covering the ulcer floor. In the regular method group, the sheets were partly elevated from the ulcer floor.
Conclusions This novel technique seems promising in this preliminary study.

• 出版日期2017-4