A graphic user interface toolkit for specification, report and comparison of dose-response relations and treatment plans using the biologically effective uniform dose

作者：Su Fan Chi^*; Mavroidis Panayiotis; Shi Chengyu; Ferreira Brigida Costa; Papanikolaou Niko

来源：Computer Methods and Programs in Biomedicine, 2010, 100(1): 69-78.

DOI：10.1016/j.cmpb.2010.02.003

• Biologically effective uniform dose
• Helical tomotherapy
• Treatment planning
• Radiobiological objectives

A toolkit (BEUDcal) has been developed for evaluating the effectiveness and for predicting the outcome of treatment plans by calculating the biologically effective uniform dose (BEUD) and complication-free tumor control probability. The input for the BEUDcal is the differential dose-volume histograms of organs exported from the treatment planning system. A clinical database is built for the dose-response parameters of different tumors and normal tissues. Dose-response probabilities of all the examined organs are illustrated together with the corresponding BEUDs and the P+ values. Furthermore, BEUDcal is able to generate a report that simultaneously presents the radiobiological evaluation together with the physical dose indices, showing the complementary relation between the physical and radiobiological treatment plan analysis performed by BEUDcal. Comparisons between treatment plans for helical tomotherapy and multileaf collimator-based intensity modulated radiotherapy of a lung patient were demonstrated to show the versatility of BEUDcal in the assessment and report of dose-response relations.

• 出版日期2010-10