An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis

作者：Sandeman Susan R^*; Howell Carol A; Phillips Gary J; Zheng Yishan; Standen Guy; Pletzenauer Robert; Davenport Andrew; Basnayake Kolitha; Boyd Owen; Holt Stephen; Mikhalovsky Sergey V

来源：Journal of Materials Science: Materials in Medicine , 2014, 25(6): 1589-1597.

DOI：10.1007/s10856-014-5173-9

Adsorbents designed with porosity which allows the removal of protein bound and high molecular weight uraemic toxins may improve the effectiveness of haemodialysis treatment of chronic kidney disease (CKD). A nanoporous activated carbon monolith prototype designed for direct blood contact was first assessed for its capacity to remove albumin bound marker toxins indoxyl sulphate (IS), p-cresyl sulphate (p-CS) and high molecular weight cytokine interleukin-6 in spiked healthy donor studies. Haemodialysis patient blood samples were then used to measure the presence of these markers in pre- and post-dialysis blood and their removal by adsorbent recirculation of post-dialysis blood samples. Nanopores (20-100 nm) were necessary for marker uraemic toxin removal during in vitro studies. Limited removal of IS and p-CS occurred during haemodialysis, whereas almost complete removal occurred following perfusion through the carbon monoliths suggesting a key role for such adsorbent therapies in CKD patient care.

• 出版日期2014-6