Anti-fibrillin-1 autoantibodies in normal pregnancy and recurrent pregnancy loss

作者：Atanasova Milena Atanasova; Konova Emiliana Ilieva^*; Aleksovska Tania Ace; Todorova Katia Nikolova; Georgieva Miglena Nikolaeva; Lukanov Tzvetan Hristoforov

来源：Autoimmunity Reviews, 2011, 10(3): 131-136.

DOI：10.1016/j.autrev.2010.09.003

• Anti-fibrillin-1 antibodies
• Fibrillin-1
• Pregnancy
• RPL

Problem: The aim of this study was to investigate anti-fibrillin-1 autoantibody in patients with a history of recurrent pregnancy loss (RPL) and during normal pregnancy.
Method of Study: Anti-fibrillin-1 IgG and IgM antibodies were measured by a home made ELISA in serum samples of 48 medically and obstetrically normal pregnant women, classified to three trimester groups, 15 female patients with RPL and 26 healthy non-pregnant women classified to two control subgroups: (a) women who had already had at least one previous successful pregnancy and (b) women who had never been pregnant. Differences in anti-fibrillin-1 autoantibodies between the groups were analyzed for statistical significance (P<0.05) with one-way analysis of variance (ANOVA) and multiple comparison test Post Hoc test, Least Significant Difference method.
Results: Anti-fibrillin-1 IgM autoantibodies were significantly decreased in the second and third trimester pregnant women compared to the nulligravida controls. RPL patients had significantly increased anti-fibrillin-1 IgM antibody compared to control group (a).
Conclusion: Fibrillin-1 degradation seems to be decreased during the second and third trimester of normal pregnancy. Increased anti-fibrillin-1 IgM antibodies in RPL patients may be a secondary phenomenon of increased fibrillin-1 degradation and contribute to the pathogenesis of pregnancy losses.

• 出版日期2011-1