Systems biology of infectious diseases: a focus on fungal infections

作者：Santamaria Rodrigo^*; Rizzetto Lisa; Bromley Michael; Zelante Teresa; Lee Wanseon; Cavalieri Duccio; Romani Luigina; Miller Brian; Gut Ivo; Santos Manuel; Pierre Philippe; Bowyer Paul; Kapushesky Misha

来源：Immunobiology, 2011, 216(11): 1212-1227.

DOI：10.1016/j.imbio.2011.08.004

• Fungal diseases
• Drug development
• Host-pathogen interaction
• Infectious diseases
• Systems biology

The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources.

• 出版日期2011-11