Aerobic Oxidative Coupling of o-Xylene: Discovery of 2-Fluoropyridine as a Ligand to Support Selective Pd-Catalyzed C-H Functionalization

作者：Izawa Yusuke; Stahl Shannon S^*

来源：Advanced Synthesis & Catalysis, 2010, 352(18): 3223-3229.

DOI：10.1002/adsc.201000771

• aerobic oxidation
• C-H activation
• industrial chemistry
• oxidation
• oxidative coupling
• palladium

An improved method for the direct oxidative coupling of o-xylene could provide streamlined access to an important monomer used in polyimide resins. The use of 2-fluoropyridine as a ligand has been found to enable unprecedented levels of chemo- and regioselectivity in this palladium-catalyzed aerobic oxidative coupling reaction. Preliminary insights have been obtained into the origin of the effectiveness of 2-fluoropyridine as a ligand.

• 出版日期2010-12-17