Associations of the fatty liver and hepatic steatosis indices with risk of cardiovascular disease: Interrelationship with age

作者：Kunutsor Setor K^*; Bakker Stephan J L; Blokzijl Hans; Dullaart Robin P F

来源：Clinica Chimica Acta, 2017, 466: 54-60.

DOI：10.1016/j.cca.2017.01.008

• Fatty liver index
• Hepatic steatosis index
• Non-alcoholic fatty liver disease
• Cardiovascular disease
• Risk factor

Background: The fatty liver index (FLI) and the hepatic steatosis index (HSI), are biomarker-based algorithms developed as proxies for non-alcoholic fatty liver disease (NAFLD). We assessed associations of FLI and HSI with cardiovascular disease (CVD) risk.
Materials and methods: The FLI and HSI were estimated at baseline in the PREVEND cohort involving 6340 participants aged 28-75 years without pre-existing CVD.
Results: During a median follow-up of 10.5 years, 631 CVD events occurred. In age-and sex-adjusted analysis, the hazard ratio (HR) (95% CI) for CVD comparing FLI >= 60 versus FLI < 30 was 1.53 (1.25-1.88); which was attenuated to 0.89 (0.70-1.13) on adjustment for conventional cardiovascular risk factors. The association remained absent after additional adjustment for potential confounders 0.85 (0.65-1.11). Comparing HSI > 36 versus HSI < 30, the corresponding adjusted HRs were 1.29 (1.02-1.65), 0.84 (0.65-1.09) and 0.79 (0.55-1.13) respectively. Subgroup analyses suggested a positive association in younger participants (<50 years) for FLI and inverse associations in older participants (>= 50 years) for both indices (P for interaction for all = 0.001).
Conclusion: Current data suggest age interactions in the association of NAFLD (as assessed by FLI or HSI) with CVD risk in a general Caucasian population.

• 出版日期2017-3