Antimicrobial Activity of Hydroxylactone obtained by Biotransformation of Bromo- and Iodolactone with Gem-Dimethylcyclohexane Ring

作者：Grabarczyk Malgorzata^*; Maczka Wanda; Winska Katarzyna; Zarowska Barbara; Aniol Miroslaw

来源：Journal of the Brazilian Chemical Society, 2013, 24(12): 1913-+.

DOI：10.5935/0103-5053.20130238

• lactones
• biotransformations
• hydrolytic dehalogenation
• Fusarium species
• antimicrobial activity

Two bicyclic lactones with gem-dimethylcyclohexane rings (delta-bromo-gamma-lactone and delta-iodo-gamma-lactone) were used as substrates for biotransformation by whole cells of several fungal strains (five cepas Fusarium, Nigrospora oryzae, Syncephalastrum racemosum, Stemphylium botryosum, Cunninghamella japonica and Acremonium sp). Some of the selected microorganisms (mainly Fusarium strains) transformed these lactones by hydrolytic dehalogenation into cis-(-)-2-hydroxy-4,4-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one. The conversion of the substrate was equal or close to 100%, showing that this method allows for the complete removal of the halogen atom from the molecule, replacing it by a hydroxy group. The structures of all substrates and products were established on the basis of their spectral data. Hydroxylactone obtained as a result of biotransformation was examined for its biological activity against bacteria, yeasts and fungi. This compound inhibits the growth of some tested microorganisms.

• 出版日期2013-12