Brain amyloid load and its associations with cognition and vascular risk factors in FINGER Study

作者：Kemppainen Nina^*; Johansson Jarkko; Teuho Jarmo; Parkkola Riitta; Joutsa Juho; Ngandu Tiia; Solomon Alina; Stephen Ruth; Liu Yawu; Hanninen Tuomo; Paajanen Teemu; Laatikainen Tiina; Soininen Hilkka; Jula Antti; Rokka Johanna; Rissanen Eero; Vahlberg Tero; Peltoniemi Julia; Kivipelto Miia; Rinne Juha O.

来源：Neurology, 2018, 90(3): E206-E213.

DOI：10.1212/WNL.0000000000004827

ObjectiveTo investigate brain amyloid pathology in a dementia-risk population defined as cardiovascular risk factors, aging, and dementia risk (CAIDE) score of at least 6 but with normal cognition and to examine associations between brain amyloid load and cognitive performance and vascular risk factors.MethodsA subgroup of 48 individuals from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) main study participated in brain C-11-Pittsburgh compound B (PiB)-PET imaging, brain MRI, and neuropsychological assessment at the beginning of the study. Lifestyle/vascular risk factors were determined as body mass index, blood pressure, total and low-density lipoprotein cholesterol, and glucose homeostasis model assessment. White matter lesions were visually rated from MRIs by a semiquantitative Fazekas score.ResultsTwenty participants (42%) had a positive PiB-PET on visual analysis. The PiB-positive group performed worse in executive functioning tests, included more participants with APOE epsilon 4 allele (50%), and showed slightly better glucose homeostasis compared to PiB-negative participants. PiB-positive and -negative participants did not differ significantly in other cognitive domain scores or other vascular risk factors. There was no significant difference in Fazekas score between the PiB groups.ConclusionsThe high percentage of PiB-positive participants provides evidence of a successful recruitment process of the at-risk population in the main FINGER intervention trial. The results suggest a possible association between early brain amyloid accumulation and decline in executive functions. APOE epsilon 4 was clearly associated with amyloid positivity, but no other risk factor was found to be associated with positive PiB-PET.

• 出版日期2018-1-16