Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients

作者：Grigoroiu Serbanescu Maria^*; Diaconu Carmen C; Heilmann Heimbach Stefanie; Neagu Ana Iulia; Becker Tim

来源：Psychiatry Research, 2015, 230(3): 964-967.

DOI：10.1016/j.psychres.2015.11.008

• EGFR
• MMP16
• CNNM2 genes

We investigated the influence of the age-of-onset (AO) on the association of 45 loci conferring risk for bipolar disorder (BP) and schizophrenia with BP-type-I in a Romanian sample (461 patients, 436 controls). The AO-analysis implicated the EGFR gene, as well as loci in other genes, in the AO variation of BP-type-I and revealed for the first time the link between BP-type-I and risk variants considered specific to schizophrenia (polymorphisms in MMP16/RIPK2 and CNNM2 genes).

• 出版日期2015-12-30