Association of Megsin gene polymorphism with IgA nephropathy risk

作者：Zhou, Tian Biao^*; Mo, Xiao Neng; Kou, Qiu Ye; Jiang, Zong Pei; Xiong, Meng Ran

来源：Journal of Receptors and Signal Transduction, 2015, 35(2): 122-126.

DOI：10.3109/10799893.2014.936461

• 2093C/T
• 2180C/T
• C25663G
• Gene polymorphism
• IgA nephropathy
• megsin
• meta-analysis

This meta-analysis was conducted to assess the association of Megsin 2093C/T, 2180C/T, C25663G gene polymorphism with the risk of IgA nephropathy (IgAN). The association literatures were identified from PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) on 1 January 2014, and eligible reports were recruited and synthesized. Seven eligible reports were recruited into this meta-analysis for the association of Megsin 2093C/T, 2180C/T, C25663G gene polymorphism with IgAN risk. In this meta-analysis, the association of Megsin 2093C/T TT genotype with IgAN risk in Asians was found. Interestingly, Megsin C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population. However, Megsin 2180C/T gene polymorphism was not associated with IgAN risk in Asians. In conclusion, Megsin 2093C/T TT genotype, and C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population. However, more studies should be performed in the future to confirm this association.

• 出版日期2015-4
• 单位中山大学