Antigen processing and presentation in the thymus: implications for T cell repertoire selection

作者：Kondo Kenta; Takada Kensuke; Takahama Yousuke^*

来源：Current Opinion in Immunology, 2017, 46: 53-57.

DOI：10.1016/j.coi.2017.03.014

The processing and presentation of major histocompatibility complex (MHC)-associated antigens depend on the intracellular digestion of self- and nonself-proteins, the loading of digested peptides onto MHC molecules, and the traffic of peptide MHC complexes to plasma membrane surface for display to interacting T cells. Recent studies have revealed unique machineries for antigen Processing and presentation in thymic antigen-presenting cells that display self-antigens to developing thymocytes for the formation of functionally competent yet self-tolerant T cell repertoire. Here, we briefly summarize those machineries, focusing on the biology of cortical and medullary thymic epithelial cells.

• 出版日期2017-6