Antiviral activity of Bignoniaceae species occurring in the State of Minas Gerais (Brazil): part 1

作者：Brandao G C; Kroon E G; dos Santos J R; Stehmann J R; Lombardi J A; de Oliveira A Braga^*

来源：Letters in Applied Microbiology, 2010, 51(4): 469-476.

DOI：10.1111/j.1472-765X.2010.02924.x

• antiviral activity
• Bignoniaceae
• EMCV
• HSV-1
• in vitro assays
• plant extracts
• VACV

Aims:
To evaluate the antiviral activity of Bignoniaceae species occurring in the state of Minas Gerais, Brazil.
Methods and Results:
Ethanol extracts of different anatomical parts of bignoniaceous plant species have been evaluated in vitro against human herpesvirus type 1 (HSV-1), vaccinia virus (VACV) and murine encephalomyocarditis virus (EMCV) by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 34 extracts from 18 plant species selected according to ethnopharmacological and taxonomic criteria were screened. Fifteen of the 34 extracts (44 center dot 1%) have disclosed antiviral activity against one or more of the viruses assayed with EC(50) values in the range of 23 center dot 2 +/- 2 center dot 5-422 center dot 7 +/- 10 center dot 9 mu g ml-1.
Conclusions:
Twelve of the 34 extracts (35 center dot 3%) might be considered promising sources of antiviral natural products, as they have shown EC(50) < 100 mu g ml-1. The present screening discloses the high potential of the Bignoniaceae family as source of antiviral agents.
Significance and Impact of the Study:
Active extracts were identified and deserve bioguided studies for the isolation of antiviral compounds and studies on mechanism of action.

• 出版日期2010-10