A Practical and Convenient Protocol for the Synthesis of (E)-alpha,beta-Unsaturated Acids

作者：Mohite Amar R; Bhat Ramakrishna G^*

来源：Organic Letters, 2013, 15(17): 4564-4567.

DOI：10.1021/ol402130t

alpha,beta-Unsaturated acids are very useful and versatile reagents in organic synthesis. A novel, practical, and convenient catalytic protocol comprising FeCl3 center dot 6H(2)O (0.5 mol %) and H2O (1 equiv) in CH3NO2 is described for the rapid synthesis of alpha,beta-unsaturated acids with high E-stereoselectivity under both microwave and conventional heating conditions with high TON and TOF values. This powerful approach efficiently demonstrated the utility of biomass derived aldehydes to build chemical agents used as fuel additives. The method proved to be scalable to gram scale synthesis.

• 出版日期2013-9-6