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摘要
The aim of the present study was to explore the association between the levels of serum N-terminal pro-B-type natriuretic peptide (NT-pro BNP) and the characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography (CCTA), in patients with unstable angina (UA). A total of 202 patients (age range, 47-82 years) were divided into the following three groups: Non-cardiac disease group (57 patients); stable angina pectoris (SAP) group (62 patients); and UA group (83 patients). There were significant differences between the serum NT-pro BNP levels among the three groups (P = 0.007). However, in multivariant diagnoses, NT-pro BNP level was not an independent risk factor for UA. The levels of serum NT-pro BNP were observed to be positively correlated with the number of vessels involved (r = 0.462; P < 0.001), SIS (r = 0.475; P < 0.001), segment-stenosis score (r = 0.453; P < 0.001), coronary calcification score (r = 0.412; P = 0.001), number of obstructive diseases (r = 0.346; P < 0.001), and the number of segments with non-calcified plaque (r = 0.235; P = 0.017), mixed plaque (r = 0.234; P = 0.017) and calcified plaque (r = 0.431; P < 0.001). The levels of serum NT-pro BNP were significantly higher in patients with UA and left main-left anterior descending (LM-LAD) disease, compared with UA patients without LM-LAD disease (P < 0.001). In addition, serum NT-pro BNP was significantly higher in patients with obstructive disease and UA than in those without obstructive disease (P < 0.001). The area under the curve of log(NT-pro BNP) was 0.656 (P = 0.006; optimal cut-off value, 1.74; sensitivity, 77.6%; specificity, 51.9%). In conclusion, the levels of serum NT-pro BNP are associated with the burden and severity of coronary artery atherosclerotic disease in patients with UA, and may be helpful in risk stratification of patients with UA.
- 出版日期2016-8
