A Rapid Tandem Knoevenagel/Michael Reaction Using Mohr's Salt as a Highly Efficient Catalyst: Green Synthesis of Bis(pyrazolyl)methanes

作者：Eskandari Khalil^*; Karami Bahador; Khodabakhshi Saeed; Farahi Mahnaz

来源：Letters in Organic Chemistry, 2015, 12(1): 38-43.

DOI：10.2174/1570178612666141204224826

• Green synthesis
• Knoevenagel condensation
• Michael addition
• aqueous media
• bis(pyrazolyl)methane
• Mohr's salt.

A convenient access to some new and known bis(pyrazolyl)methanes synthesis has been successfully achieved via an alternative Knoevenagel/Michael reaction of aromatic aldehydes and pyrazole-5-one in the presence of Mohr's salt as a green catalyst. This novel procedure has some advantages such as high efficiency, simplicity, high rate and environmental safety.

• 出版日期2015