Dual fluorescence of omeprazole: effect of solvents and pH

作者：Rajendiran N^*; Venkatesh G; Sankaranarayanan R K

来源：Physics and Chemistry of Liquids, 2014, 52(6): 738-750.

DOI：10.1080/00319104.2014.924379

• omeprazole
• solvents
• pH
• twisted intramolecular charge transfer (TICT)

Absorption, steady state fluorescence and time-resolved fluorescence spectra of omeprazole (OMP) have been studied in solvents of different polarity and pH. With an increase in the polarity of the solvents, blue shift is observed in the longer wavelength whereas red shift is noticed in the shorter wavelength band. The dual emission observed in non-polar solvents suggests that the energy of the twisted intramolecular charge transfer (TICT) state is lower than that of the locally excited (LE) state. The normal Stokes-shifted band originates from the LE state, and the large Stokes-shifted band is due to the emission from a TICT state. The Stokes shift of OMP is correlated with various solvent polarity scales like E-T(30) and f(D,n).

• 出版日期2014-11-2