Are synovial levels of WISP-1 associated with knee osteoarthritis severity and cartilage loss in elderly population?

作者：Gong, Yubao; Yang, Chen; Liu, Jianguo; Qi, Xin^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(4): 7417-7422.

• Osteoarthritis
• synovitis
• knee
• WISP-1
• radiographic
• MRI
• older adults

Objectives: WNT1 inducible signaling pathway protein-1 (WISP-1) is highly expressed in the hypertrophic zone of cartilage growth plate and has been shown to be able to induce articular cartilage damage in animal models of osteoarthritis, but its associations with Synovitis in patient with osteoarthritis has not been studied. This study aims to determine the associations between synovial levels of WISP-1 with symptoms and signs, demographic data, knee radiographic score, Synovitis degree and cartilage loss in osteoarthritis (OA) patients. Methods: A total of 89 randomly selected subjects (mean 63 years old, ranging 52-78 years old, 73% female) were studied. Demographic data were documented. Synovial level of WISP-1 was assessed by enzyme-linked immunosorbent assay (ELISA) kits. The grading of OA was determined by Kellgren/Lawrence score. Synovitis severity was assessed using MRI. The loss of cartilage was assessed by whole-organ MRI scoring (WORMS). Pearson's correlation coefficient (r) was used to determine correlations among WISP-1 level with symptoms and signs of OA, demographic data, knee radiographic score, synovitis severity and cartilage loss. Results: The synovial fluid WISP-1 level in knees of OA patients was significantly higher in OA patient group with synovitis than in group without synovitis (P<0.001). Moreover, there was no difference in WOMAC score or WORMS score between these two groups. The synovial fluid WISP-1 level was not correlated with severity of OA damage shown by radiography (r=0.004, P=0.981). Conclusions: These findings indicate that the synovial fluid WISP-1 level is correlated with synovitis in patient with osteoarthritis and may be used as a clinical indicator to facilitate the diagnosis, evaluation and treatment of synovitis in patient with osteoarthritis.

• 出版日期2016
• 单位吉林大学