The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome

作者：Livadas Sarantis; Boutzios Georgios; Economou Fragiskos; Alexandraki Krystallenia; Xyrafis Xenofon; Christou Maria; Zerva Aristea; Karachalios Athanasios; Tantalaki Evangelia; Diamanti Kandarakis Evanthia^*

来源：Fertility and Sterility, 2010, 94(1): 242-246.

DOI：10.1016/j.fertnstert.2009.02.073

• Androgens
• progesterone
• hyperandrogenism
• polycystic ovary syndrome
• HOMA-IR

Objective: To investigate the effects of oral natural micronized P on hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS) and to answer the clinical question whether induction of withdrawal bleeding is a necessity for the comparison of hormonal and metabolic data in subjects with PCOS.
Design: Prospective clinical study.
Setting: Academic medical center.
Patient(s): Twenty-eight reproductive-aged women with PCOS.
Main Outcome Measure(s): Blood sampling was collected at baseline, after 7 days of oral natural micronized P (200 mg) administration, and after withdrawal bleeding. At these three stages hormonal parameters and homeostasis assessment model (HOMA-IR) index were assessed in all patients.
Result(s): Oral natural micronized P administration did not alter significantly insulin sensitivity index and androgen levels; however, LH was decreased when postbleeding values were compared to baseline. Nevertheless, after oral natural micronized P administration, P and 17 alpha-hydroxyprogesterone (17-OHP) concentrations were increased, and HOMA-IR was decreased, whereas androgens levels were not altered, in comparison with baseline.
Conclusion(s): The induction of withdrawal bleeding, with this regimen, does not appear to be a necessity for the assessment of hormonal and metabolic profile in anovulatory women with PCOS. (Fertil Steril (R) 2010; 94: 242-6.

• 出版日期2010-6