Association between serum CA 19-9 and metabolic syndrome: A cross-sectional study

作者：Du, Rui; Cheng, Di; Lin, Lin; Sun, Jichao; Peng, Kui; Xu, Yu; Xu, Min; Chen, Yuhong; Bi, Yufang; Wang, Weiqing; Lu, Jieli^*; Ning, Guang

来源：Journal of Diabetes, 2017, 9(11): 1040-1047.

DOI：10.1111/1753-0407.12523

• association
• CA 19-9
• metabolic syndrome

BackgroundIncreasing evidence suggests that serum CA 19-9 is associated with abnormal glucose metabolism. However, data on the association between CA 19-9 and metabolic syndrome is limited. The aim of the present study was to investigate the association between serum CA 19-9 and metabolic syndrome. @@@ MethodsA cross-sectional study was conducted on 3641 participants aged 40years from the Songnan Community, Baoshan District in Shanghai, China. Logistic regression analysis was used to evaluate the association between serum CA 19-9 and metabolic syndrome. @@@ ResultsMultivariate logistic regression analysis showed that compared with participants in the first tertile of serum CA 19-9, those in the second and third tertiles had increased odds ratios (OR) for prevalent metabolic syndrome (multivariate adjusted OR 1.46 [95% confidence interval {CI} 1.11-1.92] and 1.51 [95% CI 1.14-1.98]; P-trend=0.005). In addition, participants with elevated serum CA 19-9 (37U/mL) had an increased risk of prevalent metabolic syndrome compared with those with serum CA 19-9< 37U/mL (multivariate adjusted OR 2.10; 95% CI 1.21-3.65). @@@ ConclusionSerum CA 19-9 is associated with an increased risk of prevalent metabolic syndrome. In order to confirm this association and identify potential mechanisms, prospective cohort and mechanic studies should be performed.

• 出版日期2017-11
• 单位上海交通大学; 上海市闵行区中心医院