Association between Density of Coronary Artery Calcification and Serum Magnesium Levels among Patients with Chronic Kidney Disease

作者：Sakaguchi Yusuke; Hamano Takayuki; Nakano Chikako; Obi Yoshitsugu; Matsui Isao; Kusunoki Yasuo; Mori Daisuke; Oka Tatsufumi; Hashimoto Nobuhiro; Takabatake Yoshitsugu; Takahashi Atsushi; Kaimori Jun Ya; Moriyama Toshiki; Yamamoto Ryohei; Horio Masaru; Sugimoto Ken; Yamamoto Koichi; Rakugi Hiromi; Isaka Yoshitaka

来源：PLos One, 2016, 11(9): e0163673.

DOI：10.1371/journal.pone.0163673

Background
The Agatston score, commonly used to quantify coronary artery calcification (CAC), is determined by the plaque area and density. Despite an excellent predictability of the Agatston score for cardiovascular events, the density of CAC has never been studied in patients with pre-dialysis chronic kidney disease (CKD). This study aimed to analyze the CAC density and its association with serum mineral levels in CKD.
Methods
We enrolled patients with pre-dialysis CKD who had diabetes mellitus, prior cardiovascular disease history, elevated low-density lipoprotein cholesterol levels, or smoking history. The average CAC density was calculated by dividing the Agatston score by the total area of CAC.
Results
The mean estimated glomerular filtration rate (eGFR) of 109 enrolled patients was 35.7 mL/min/1.73 m(2). The correlation of the Agatston score with density was much weaker than that with the total area (R-2 = 0.19, P < 0.001; and R-2 = 0.99, P < 0.001, respectively). Multivariate analyses showed that serum magnesium level was inversely associated with the density, but not with the total area, after adjustment for demographics and clinical factors related to malnutrition-inflammation-atherosclerosis syndrome and mineral and bone disorders including fibroblast growth factor 23 (P = 0.006). This inverse association was pronounced among patients with higher serum phosphate levels (P for interaction = 0.02).
Conclusion
CAC density was inversely associated with serum magnesium levels, particularly in patients with higher serum phosphate levels.

• 出版日期2016-9-23