Nonlinear Pressure Dependence of the Interaction Potential of Dense Protein Solutions

作者:Schroer Martin A*; Markgraf Jonas; Wieland D C Florian; Sahle Christoph J; Moeller Johannes; Paulus Michael; Tolan Metin; Winter Roland
来源:Physical Review Letters, 2011, 106(17): 178102.
DOI:10.1103/PhysRevLett.106.178102

摘要

The influence of pressure on the structure and protein-protein interaction potential of dense protein solutions was studied and analyzed using small-angle x-ray scattering in combination with a liquid state theoretical approach. The structural as well as the interaction parameters of dense lysozyme solutions are affected by pressure in a nonlinear way. The structural properties of water lead to a modification of the protein-protein interactions below 4 kbar, which might have significant consequences for the stability of proteins in extreme natural environments.

  • 出版日期2011-4-26